Two representative situations were selected: a Krogh cylinder geometry with heterogeneous hemoglobin saturation (HS) at the inflow, and a parallel array of four capillaries. Models for the evolution of hemoglobin saturation heterogeneity (HSH) in capillary networks were developed and validated using a computational model with moving RBCs. Here we examine the relation between CTH and capillary outflow saturation heterogeneity (COSH), which is the heterogeneity of blood oxygen content at the venous end of capillaries. However, the transit time of red blood cells (RBCs) through the microvasculature is not a direct measure of their capacity for oxygen delivery. Disturbed capillary flow patterns have been shown to limit the efficacy of oxygen extraction and can be quantified using capillary transit time heterogeneity (CTH). 3Institute of Pharmacology and Toxicology, University of Zurich, Zurich, SwitzerlandĬapillary dysfunction impairs oxygen supply to parenchymal cells and often occurs in Alzheimer's disease, diabetes and aging.2Department of Physiology, University of Arizona, Tucson, AZ, United States.1Department of Mechanical and Process Engineering, Institute of Fluid Dynamics, ETH Zurich, Zurich, Switzerland.Secomb 2, Bruno Weber 3 and Patrick Jenny 1
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